Interbilayer-Crosslinked Multilamellar Vesicles as Synthetic Vaccines for Potent Humoral and Cellular Immune Responses

Vaccines based on recombinant proteins avoid toxicity and anti-vector immunity associated with live vaccine (e.g., viral) vectors, but their immunogenicity is poor, particularly for CD8(+) T-cell (CD8T) responses. Synthetic particles carrying antigens and adjuvant molecules have been developed to en...

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Hauptverfasser: Moon, James J., Suh, Heikyung, Bershteyn, Anna, Stephan, Matthias T., Liu, Haipeng, Huang, Bonnie, Sohail, Mashaal, Luo, Samantha, Um, Soong Ho, Khant, Htet, Goodwin, Jessica T., Ramos, Jenelyn, Chiu, Wah, Irvine, Darrell J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077947/
https://ncbi.nlm.nih.gov/pubmed/21336265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmat2960
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