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LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in C. elegans
The highly conserved let-7 microRNA (miRNA) regulates developmental pathways across animal phyla. Mis-expression of let-7 causes lethality in Caenorhabditis elegans and has been associated with several human diseases. We show that timing of let-7 expression in developing worms is under complex trans...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3077891/ https://ncbi.nlm.nih.gov/pubmed/21297634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1986 |
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