Influence of Affinity and Antigen Internalization on the Uptake and Penetration of Anti-HER2 Antibodies in Solid Tumors

Antibody drugs are widely used in cancer therapy, but conditions to maximize tumor penetration and efficacy have yet to be fully elucidated. In this study, we investigated the impact of antibody binding affinity on tumor targeting and penetration with affinity variants that recognize the same epitop...

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Bibliographic Details
Main Authors: Rudnick, Stephen I., Lou, Jianlong, Shaller, Calvin C., Tang, Yong, Klein-Szanto, Andres J.P., Weiner, Louis M., Marks, James D., Adams, Gregory P.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077882/
https://ncbi.nlm.nih.gov/pubmed/21406401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2277
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