Combinatorial Tau Pseudophosphorylation: MARKEDLY DIFFERENT REGULATORY EFFECTS ON MICROTUBULE ASSEMBLY AND DYNAMIC INSTABILITY THAN THE SUM OF THE INDIVIDUAL PARTS

Tau is a multiply phosphorylated protein that is essential for the development and maintenance of the nervous system. Errors in Tau action are associated with Alzheimer disease and related dementias. A huge literature has led to the widely held notion that aberrant Tau hyperphosphorylation is centra...

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Main Authors: Kiris, Erkan, Ventimiglia, Donovan, Sargin, Mehmet E., Gaylord, Michelle R., Altinok, Alphan, Rose, Kenneth, Manjunath, B. S., Jordan, Mary Ann, Wilson, Leslie, Feinstein, Stuart C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077627/
https://ncbi.nlm.nih.gov/pubmed/21288907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.219311
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