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Macrophage-specific Up-regulation of Apolipoprotein E Gene Expression by STAT1 Is Achieved via Long Range Genomic Interactions

In atherogenesis, macrophage-derived apolipoprotein E (apoE) has an athero-protective role by a mechanism that is not fully understood. We investigated the regulatory mechanisms involved in the modulation of apoE expression in macrophages. The experiments showed that the promoters of all genes of th...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Trusca, Violeta Georgeta, Fuior, Elena Valeria, Florea, Irina Cristina, Kardassis, Dimitris, Simionescu, Maya, Gafencu, Anca Violeta
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077590/
https://ncbi.nlm.nih.gov/pubmed/21372127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.179572
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