Macrophage-specific Up-regulation of Apolipoprotein E Gene Expression by STAT1 Is Achieved via Long Range Genomic Interactions

In atherogenesis, macrophage-derived apolipoprotein E (apoE) has an athero-protective role by a mechanism that is not fully understood. We investigated the regulatory mechanisms involved in the modulation of apoE expression in macrophages. The experiments showed that the promoters of all genes of th...

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Detalhes bibliográficos
Main Authors: Trusca, Violeta Georgeta, Fuior, Elena Valeria, Florea, Irina Cristina, Kardassis, Dimitris, Simionescu, Maya, Gafencu, Anca Violeta
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077590/
https://ncbi.nlm.nih.gov/pubmed/21372127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.179572
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