Angiotensin-Converting Enzyme 2 Activation Protects Against Hypertension-Induced Cardiac Fibrosis Involving Extracellular Signal-Regulated Kinases

Our previous studies have indicated that chronic treatment with XNT (1-[(2-dimethylamino) ethylamino]-4-(hydroxymethyl)-7-[(4-methylphenyl) sulfonyl oxy]-9H-xanthene-9-one), an angiotensin-converting enzyme2 (ACE2) activator, reverses hypertension-induced cardiac and renal fibrosis in spontaneously...

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Main Authors: Ferreira, Anderson J., Shenoy, Vinayak, Qi, Yanfei, Fraga-Silva, Rodrigo A., Santos, Robson A.S., Katovich, Michael J., Raizada, Mohan K.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077555/
https://ncbi.nlm.nih.gov/pubmed/21148624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/expphysiol.2010.055277
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