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Implications of the presence of N-glycolylneuraminic Acid in Recombinant Therapeutic Glycoproteins
Recombinant glycosylated biotherapeutic agents are usually produced in non-human mammalian cell lines, which can synthesize and/or metabolically incorporate the non-human sialic acid N-glycolylneuraminic acid (Neu5Gc). This contamination was previously known but ignored, as normal humans were though...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3077421/ https://ncbi.nlm.nih.gov/pubmed/20657583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1651 |
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