Thrombospondin 1 is a key mediator of transforming growth factor β-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism

BACKGROUND: The mechanism underlying the ability of fibroblasts to contract a collagen gel matrix is largely unknown. Fibroblasts from scarred (lesional) areas of patients with the fibrotic disease scleroderma show enhanced ability to contract collagen relative to healthy fibroblasts. Thrombospondin...

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Detalhes bibliográficos
Main Authors: Chen, Yunliang, Leask, Andrew, Abraham, David J, Kennedy, Laura, Shi-wen, Xu, Denton, Christopher P, Black, Carol M, Verjee, Liaquat S, Eastwood, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077328/
https://ncbi.nlm.nih.gov/pubmed/21453480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-1536-4-9
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