Beyond reduction of atherosclerosis: PON2 provides apoptosis resistance and stabilizes tumor cells

Major contributors to atherosclerosis are oxidative damage and endoplasmic reticulum (ER) stress-induced apoptosis; both of which can be diminished by the anti-oxidative protein paraoxonase-2 (PON2). ER stress is also relevant to cancer and associated with anti-cancer treatment resistance. Hence, we...

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Hlavní autoři: Witte, I, Altenhöfer, S, Wilgenbus, P, Amort, J, Clement, A M, Pautz, A, Li, H, Förstermann, U, Horke, S
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2011
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077287/
https://ncbi.nlm.nih.gov/pubmed/21368884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2010.91
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