One Enzyme, Two Functions: PON2 PREVENTS MITOCHONDRIAL SUPEROXIDE FORMATION AND APOPTOSIS INDEPENDENT FROM ITS LACTONASE ACTIVITY

The human enzyme paraoxonase-2 (PON2) has two functions, an enzymatic lactonase activity and the reduction of intracellular oxidative stress. As a lactonase, it dominantly hydrolyzes bacterial signaling molecule 3OC12 and may contribute to the defense against pathogenic Pseudomonas aeruginosa. By it...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Altenhöfer, Sebastian, Witte, Ines, Teiber, John F., Wilgenbus, Petra, Pautz, Andrea, Li, Huige, Daiber, Andreas, Witan, Heidrun, Clement, Albrecht M., Förstermann, Ulrich, Horke, Sven
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2010
Gaiak:
Cell Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2915675/
https://ncbi.nlm.nih.gov/pubmed/20530481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.118604
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