Structure and function of a HECT domain ubiquitin-binding site

The Rsp5 ubiquitin ligase contains a non-covalent binding site for ubiquitin within the amino-terminal lobe (N-lobe) of the HECT domain, and the X-ray crystal structure of the HECT–ubiquitin complex has been determined. Hydrophobic patch residues of ubiquitin (L8, I44, V70) were crucial for interact...

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Bibliografiske detaljer
Main Authors: Kim, Hyung Cheol, Steffen, Alanna M, Oldham, Michael L, Chen, Jue, Huibregtse, Jon M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Scientific Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077248/
https://ncbi.nlm.nih.gov/pubmed/21399621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.23
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