Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis

Lithocholic acid (LCA) is an endogenous compound associated with hepatic toxicity during cholestasis. LCA exposure in mice resulted in decreased serum lysophosphatidylcholine (LPC) and sphingomyelin levels due to elevated lysophosphatidylcholine acyltransferase (LPCAT) and sphingomyelin phosphodiest...

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Hauptverfasser: Matsubara, Tsutomu, Tanaka, Naoki, Patterson, Andrew D., Cho, Joo-Youn, Krausz, Kristopher W., Gonzalez, Frank J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077083/
https://ncbi.nlm.nih.gov/pubmed/21480330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24193
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