An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway

Misregulated β-catenin responsive transcription (CRT) has been implicated in the genesis of various malignancies, including colorectal carcinomas, and it is a key therapeutic target in combating various cancers. Despite significant effort, successful clinical implementation of CRT inhibitory therape...

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Autors principals: Gonsalves, Foster C., Klein, Keren, Carson, Brittany B., Katz, Shauna, Ekas, Laura A., Evans, Steve, Nagourney, Robert, Cardozo, Timothy, Brown, Anthony M. C., DasGupta, Ramanuj
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
Matèries:
Feature Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076864/
https://ncbi.nlm.nih.gov/pubmed/21393571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017496108
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