A case study of the reproducibility of transcriptional reporter cell-based RNAi screens in Drosophila

Off-target effects have been demonstrated to be a major source of false-positives in RNA interference (RNAi) high-throughput screens. In this study, we re-assess the previously published transcriptional reporter-based whole-genome RNAi screens for the Wingless and Hedgehog signaling pathways using s...

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Dettagli Bibliografici
Autori principali: DasGupta, Ramanuj, Nybakken, Kent, Booker, Matthew, Mathey-Prevot, Bernard, Gonsalves, Foster, Changkakoty, Binita, Perrimon, Norbert
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2007
Soggetti:
Method
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2375041/
https://ncbi.nlm.nih.gov/pubmed/17903264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2007-8-9-r203
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