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Efficient Intracellular Delivery of a Pro-Apoptotic Peptide With A pH-Responsive Carrier
A key challenge in developing protein therapeutics or imaging agents that work against cytosolic targets is the intracellular delivery barrier. Here, we show that the pH-responsive, membrane-destabilizing polymer, poly (propylacrylic acid) (PPAA), can strongly enhance target cell killing through the...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3076797/ https://ncbi.nlm.nih.gov/pubmed/21499545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.reactfunctpolym.2010.09.008 |
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