Expression of sulfotransferase isoform 1A1 (SULT1A1) in breast cancer cells significantly increases 4-hydroxytamoxifen-induced apoptosis

Previously, we reported a strong association of the high activity SULT1A1*1 allele and overall survival of patients receiving tamoxifen therapy, indicating that sulfation of 4-hydroxytamoxifen (4-OHT) via SULT1A1 may contribute to the therapeutic efficacy of tamoxifen treatment. In most, but not all...

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Autori principali: Mercer, Kelly E, Apostolov, Eugene O, da Costa, Goncalo Gamboa, Yu, Xinfeng, Lang, Patrick, Roberts, Dean W, Davis, Warren, Basnakian, Alexei G, Kadlubar, Fred F, Kadlubar, Susan A
Natura: Artigo
Lingua:Inglês
Pubblicazione: e-Century Publishing Corporation 2010
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076764/
https://ncbi.nlm.nih.gov/pubmed/21537383
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