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Sirolimus enhances the magnitude and quality of viral-specific CD8(+) T cell responses to vaccinia virus vaccination in rhesus macaques

Sirolimus is a potent anti-proliferative agent used clinically to prevent renal allograft rejection. However, little is known about the effects of maintenance immunosuppressive agents on the immune response to potentially protective vaccines. Here we show that sirolimus paradoxically increases the m...

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Detalhes bibliográficos
Main Authors: Turner, Alexandra P., Shaffer, Virginia Oliva, Araki, Koichi, Martens, Christine, Turner, Pamela L., Gangappa, Shivaprakash, Ford, Mandy L., Ahmed, Rafi, Kirk, Allan D., Larsen, Christian P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076606/
https://ncbi.nlm.nih.gov/pubmed/21342450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-6143.2010.03407.x
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