Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells

Breast cancer is a genetically and clinically heterogeneous disease, and the contributions of different target cells and different oncogenic mutations to this heterogeneity are not well understood. Here we report that mammary tumors induced by components of the Wnt signaling pathway contain heteroge...

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Hlavní autoři: Li, Yi, Welm, Bryan, Podsypanina, Katrina, Huang, Shixia, Chamorro, Mario, Zhang, Xiaomei, Rowlands, Tracey, Egeblad, Mikala, Cowin, Pam, Werb, Zena, Tan, Lee K., Rosen, Jeffrey M., Varmus, Harold E.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2003
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC307657/
https://ncbi.nlm.nih.gov/pubmed/14668450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2136825100
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