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Why Do Some Fischer Indolizations Fail?

The mechanisms of the Fischer indole synthesis and competing cleavage pathways were explored with SCS-MP2/6-31G(d) and aqueous solvation calculations. Electron-donating substituents divert the reaction pathway to heterolytic N–N bond cleavage and preclude the acid-promoted [3,3]-sigmatropic rearrang...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Çelebi-Ölçüm, Nihan, Boal, Ben W., Huters, Alexander D., Garg, Neil K., Houk, K. N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076556/
https://ncbi.nlm.nih.gov/pubmed/21443189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja201035b
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