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A Peptide Mimetic of the Connexin43 Carboxyl-Terminus Reduces Gap Junction Remodeling and Induced Arrhythmia Following Ventricular Injury
RATIONALE: Remodeling of connexin-43 (Cx43) gap junctions (GJs) is linked to ventricular arrhythmia. OBJECTIVES: A peptide mimetic of the carboxyl-terminal (CT) of Cx43, incorporating a Post-synaptic-density/Disks-large/ZO-1 (PDZ)-binding domain, reduces Cx43/ZO-1 interaction and GJ size remodeling...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3076085/ https://ncbi.nlm.nih.gov/pubmed/21273554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.235747 |
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