Aerosol Vaccination Induces Robust Protective Immunity to Homologous and Heterologous Influenza Infection in Mice

Live-attenuated influenza vaccine (LAIV) delivered by large droplet intranasal spray is efficacious against infection. However, many of the large droplets are trapped in the external nares and do not reach the target nasal airway tissues. Smaller droplets might provide better distribution yielding s...

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Detalhes bibliográficos
Main Authors: Smith, Jennifer Humberd, Brooks, Paula, Johnson, Scott, Tompkins, S. Mark, Custer, Koren M., Haas, Debra L., Mair, Raydel, Papania, Mark, Tripp, Ralph A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076080/
https://ncbi.nlm.nih.gov/pubmed/21300100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2011.01.059
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