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Regulation of a muralytic enzyme by dynamic membrane topology
R(21), the lysozyme of coliphage 21, has a N-terminal Signal-Anchor-Release (SAR) domain that directs its secretion in a membrane-tethered, inactive form and then its release and activation in the periplasm. Both genetic and crystallographic studies reveal that the SAR domain, once extracted from th...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3075974/ https://ncbi.nlm.nih.gov/pubmed/19881499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1681 |
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