Ultrafast folding of α(3)D: A de novo designed three-helix bundle protein
Here, we describe the folding/unfolding kinetics of α(3)D, a small designed three-helix bundle. Both IR temperature jump and ultrafast fluorescence mixing methods reveal a single-exponential process consistent with a minimal folding time of 3.2 ± 1.2 μs (at ≈50°C), indicating that a protein can fold...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2003
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307594/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14671331/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2136623100 |
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