Ultrafast folding of α(3)D: A de novo designed three-helix bundle protein

Here, we describe the folding/unfolding kinetics of α(3)D, a small designed three-helix bundle. Both IR temperature jump and ultrafast fluorescence mixing methods reveal a single-exponential process consistent with a minimal folding time of 3.2 ± 1.2 μs (at ≈50°C), indicating that a protein can fold...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Zhu, Yongjin, Alonso, Darwin O. V., Maki, Kosuke, Huang, Cheng-Yen, Lahr, Steven J., Daggett, Valerie, Roder, Heinrich, DeGrado, William F., Gai, Feng
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC307594/
https://ncbi.nlm.nih.gov/pubmed/14671331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2136623100
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares