Ultrafast folding of α(3)D: A de novo designed three-helix bundle protein

Here, we describe the folding/unfolding kinetics of α(3)D, a small designed three-helix bundle. Both IR temperature jump and ultrafast fluorescence mixing methods reveal a single-exponential process consistent with a minimal folding time of 3.2 ± 1.2 μs (at ≈50°C), indicating that a protein can fold...

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Bibliographic Details
Main Authors:	Zhu, Yongjin, Alonso, Darwin O. V., Maki, Kosuke, Huang, Cheng-Yen, Lahr, Steven J., Daggett, Valerie, Roder, Heinrich, DeGrado, William F., Gai, Feng
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 2003
Subjects:	Biological Sciences
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC307594/ https://ncbi.nlm.nih.gov/pubmed/14671331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2136623100
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Ultrafast folding of α(3)D: A de novo designed three-helix bundle protein

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