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Molecular targeting of Glioblastoma – how do you hit a moving target?
Cancer is a molecularly complex, genomically unstable disease. Selection for drug resistance mutations, activation of feedback loops and upregulation of cross-talk pathways provide escape routes by which cancer cells maintain signal flux through critical downstream effectors to promote therapeutic r...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3075730/ https://ncbi.nlm.nih.gov/pubmed/21208902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-2268 |
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