Protection of Cftr knockout mice from acute lung infection by a helper-dependent adenoviral vector expressing Cftr in airway epithelia

We developed a helper-dependent adenoviral vector for cystic fibrosis lung gene therapy. The vector expresses cystic fibrosis transmembrane conductance regulator (Cftr) using control elements from cytokeratin 18. The vector expressed properly localized CFTR in cultured cells and in the airway epithe...

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Detalhes bibliográficos
Main Authors: Koehler, David R., Sajjan, Umadevi, Chow, Yu-Hua, Martin, Bernard, Kent, Geraldine, Tanswell, A. Keith, McKerlie, Colin, Forstner, Janet F., Hu, Jim
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC307573/
https://ncbi.nlm.nih.gov/pubmed/14673110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2436478100
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