Nucleo-cytosolic Shuttling of FoxO1 Directly Regulates Mouse Ins2 but Not Ins1 Gene Expression in Pancreatic Beta Cells (MIN6)

The Forkhead box transcription factor FoxO1 regulates metabolic gene expression in mammals. FoxO1 activity is tightly controlled by phosphatidylinositol 3-kinase (PI3K) signaling, resulting in its phosphorylation and nuclear exclusion. We sought here to determine the mechanisms involved in glucose a...

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Autori principali: Meur, Gargi, Qian, Qingwen, da Silva Xavier, Gabriela, Pullen, Timothy J., Tsuboi, Takashi, McKinnon, Caroline, Fletcher, Laura, Tavaré, Jeremy M., Hughes, Stephen, Johnson, Paul, Rutter, Guy A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075709/
https://ncbi.nlm.nih.gov/pubmed/21335550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.204248
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