Nucleo-cytosolic Shuttling of FoxO1 Directly Regulates Mouse Ins2 but Not Ins1 Gene Expression in Pancreatic Beta Cells (MIN6)

The Forkhead box transcription factor FoxO1 regulates metabolic gene expression in mammals. FoxO1 activity is tightly controlled by phosphatidylinositol 3-kinase (PI3K) signaling, resulting in its phosphorylation and nuclear exclusion. We sought here to determine the mechanisms involved in glucose a...

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Detalhes bibliográficos
Main Authors: Meur, Gargi, Qian, Qingwen, da Silva Xavier, Gabriela, Pullen, Timothy J., Tsuboi, Takashi, McKinnon, Caroline, Fletcher, Laura, Tavaré, Jeremy M., Hughes, Stephen, Johnson, Paul, Rutter, Guy A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075709/
https://ncbi.nlm.nih.gov/pubmed/21335550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.204248
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