Amyloid Features and Neuronal Toxicity of Mature Prion Fibrils Are Highly Sensitive to High Pressure

Prion proteins (PrP) can aggregate into toxic and possibly infectious amyloid fibrils. This particular macrostructure confers on them an extreme and still unexplained stability. To provide mechanistic insights into this self-assembly process, we used high pressure as a thermodynamic tool for perturb...

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Detalhes bibliográficos
Main Authors: El Moustaine, Driss, Perrier, Veronique, Van Ba, Isabelle Acquatella-Tran, Meersman, Filip, Ostapchenko, Valeriy G., Baskakov, Ilia V., Lange, Reinhard, Torrent, Joan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075691/
https://ncbi.nlm.nih.gov/pubmed/21357423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.192872
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