Amyloid Features and Neuronal Toxicity of Mature Prion Fibrils Are Highly Sensitive to High Pressure

Prion proteins (PrP) can aggregate into toxic and possibly infectious amyloid fibrils. This particular macrostructure confers on them an extreme and still unexplained stability. To provide mechanistic insights into this self-assembly process, we used high pressure as a thermodynamic tool for perturb...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: El Moustaine, Driss, Perrier, Veronique, Van Ba, Isabelle Acquatella-Tran, Meersman, Filip, Ostapchenko, Valeriy G., Baskakov, Ilia V., Lange, Reinhard, Torrent, Joan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2011
Gaiak:
Protein Structure and Folding
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075691/
https://ncbi.nlm.nih.gov/pubmed/21357423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.192872
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