IL-17-induced NF-κB Activation via CIKS/Act1: PHYSIOLOGIC SIGNIFICANCE AND SIGNALING MECHANISMS

Interleukin-17 (IL-17) is essential in host defense against extracellular bacteria and fungi, especially at mucosal sites, but it also contributes significantly to inflammatory and autoimmune disease pathologies. Binding of IL-17 to its receptor leads to recruitment of adaptor protein CIKS/Act1 via...

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Main Authors: Sønder, Søren Ulrik, Saret, Sun, Tang, Wanhu, Sturdevant, Dan E., Porcella, Stephen F., Siebenlist, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075635/
https://ncbi.nlm.nih.gov/pubmed/21335551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.199547
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