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ALKYLATING TRYPTIC PEPTIDES TO ENHANCE ESI-MS ANALYSIS

A major limitation of mass spectrometry-based proteomics is inefficient and differential ionization during electrospray ionization (ESI). This leads to problems such as increased limits-of-detection and incomplete sequence coverage of proteins. Incomplete sequence coverage is especially problematic...

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Detalhes bibliográficos
Main Authors: Kulevich, Suzanne E., Frey, Brian L., Kreitinger, Gloria, Smith, Lloyd M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075559/
https://ncbi.nlm.nih.gov/pubmed/21114270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac1019792
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