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Guanidination of Tryptic Peptides without Desalting for MALDI-TOF MS Analysis
Derivatizations that enhance mass spectral quality often require desalting which presents as a bottleneck in MALDI-TOF MS-proteomics. Guanidination, which converts lysine to homoarginine, an arginine analog, can increase detection of those peptides 5 – 15-fold. Our aim was to improve guanidination b...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3820968/ https://ncbi.nlm.nih.gov/pubmed/23964694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac402246r |
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