Inhibition of renal caveolin-1 reduces natriuresis and produces hypertension in sodium-loaded rats

Renal dopamine receptor function and ion transport inhibition are impaired in essential hypertension. We recently reported that caveolin-1 (CAV1) and lipid rafts are necessary for normal D(1)-like receptor-dependent internalization of Na-K-ATPase in human proximal tubule cells. We now hypothesize th...

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Main Authors: Gildea, John J., Kemp, Brandon A., Howell, Nancy L., Van Sciver, Robert E., Carey, Robert M., Felder, Robin A.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074998/
https://ncbi.nlm.nih.gov/pubmed/21289050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00380.2010
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