Glioblastoma Recurrence after Cediranib Therapy in Patients: Lack of “Rebound” Revascularization as Mode of Escape

Recurrent glioblastomas (rGBM) invariably relapse after initial response to anti-VEGF therapy. There are two prevailing hypotheses on how these tumors escape antiangiogenic therapy: switch to VEGF-independent angiogenic pathways and vessel co-option. However, direct evidence in rGBM patients is lack...

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Detalhes bibliográficos
Main Authors: di Tomaso, Emmanuelle, Snuderl, Matija, Kamoun, Walid S., Duda, Dan G., Auluck, Pavan K., Fazlollahi, Ladan, Andronesi, Ovidiu C., Frosch, Matthew P., Wen, Patrick Y., Plotkin, Scott R., Hedley-Whyte, E. Tessa, Sorensen, A. Gregory, Batchelor, Tracy T., Jain, Rakesh K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074948/
https://ncbi.nlm.nih.gov/pubmed/21199795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2602
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