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Peptide length and prime-side sterics influence potency of peptide phosphonate protease inhibitors
The ability to follow enzyme activity in a cellular context represents a challenging technological frontier that impacts fields ranging from disease pathogenesis to epigenetics. Activity-based probes (ABPs) label the active form of an enzyme via covalent modification of catalytic residues. Here we p...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3074588/ https://ncbi.nlm.nih.gov/pubmed/21276938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.11.007 |
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