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Peptide length and prime-side sterics influence potency of peptide phosphonate protease inhibitors

The ability to follow enzyme activity in a cellular context represents a challenging technological frontier that impacts fields ranging from disease pathogenesis to epigenetics. Activity-based probes (ABPs) label the active form of an enzyme via covalent modification of catalytic residues. Here we p...

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Detalhes bibliográficos
Main Authors: Brown, Christopher M., Ray, Manisha, Eroy-Reveles, Aura A., Egea, Pascal, Tajon, Cheryl, Craik, Charles S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074588/
https://ncbi.nlm.nih.gov/pubmed/21276938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.11.007
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