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Overexpression of Tissue VEGF-A May Portend an Increased Likelihood of Progression in a Phase II Trial of Bevacizumab and Erlotinib in Resistant Ovarian Cancer

PURPOSE: This phase II trial evaluated bevacizumab plus erlotinib in platinum-resistant ovarian cancer; exploratory biomarker analyses, including that of tumor vascular endothelial growth factor (VEGF-A), were also performed. EXPERIMENTAL DESIGN: Forty heavily pretreated patients received erlotinib...

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Autori principali: Chambers, Setsuko K., Clouser, Mary C., Baker, Amanda F., Roe, Denise J., Cui, Haiyan, Brewer, Molly A., Hatch, Kenneth D., Gordon, Michael S., Janicek, Mike F., Isaacs, Jeffrey D., Gordon, Alan N., Nagle, Raymond B., Wright, Heather M., Cohen, Janice L., Alberts, David S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074583/
https://ncbi.nlm.nih.gov/pubmed/21041183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-0974
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