Loss of TGF-β type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-α-, MSP- and HGF-mediated signaling networks

Stromal fibroblasts regulate epithelial cell behavior through direct and indirect cell–cell interactions. To clarify the role of TGF-β signaling in stromal fibroblasts during mammary development and tumorigenesis, we conditionally knocked out the TGF-β type II receptor gene in mouse mammary fibrobla...

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Hauptverfasser: Cheng, Nikki, Bhowmick, Neil A, Chytil, Anna, Gorksa, Agnieszka E, Brown, Kimberly A, Muraoka, Rebecca, Arteaga, Carlos L, Neilson, Eric G, Hayward, Simon W, Moses, Harold L
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074577/
https://ncbi.nlm.nih.gov/pubmed/15856015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1208685
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