Human Toll-like receptor 4 responses to P. gingivalis are regulated by lipid A 1- and 4'- phosphatase activities

Signal transduction following binding of lipopolysaccharide (LPS) to Toll-like receptor 4 (TLR4) is an essential aspect of host innate immune responses to infection by Gram-negative pathogens. Here, we describe a novel molecular mechanism used by a prevalent human bacterial pathogen to evade and sub...

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Détails bibliographiques
Auteurs principaux: Coats, Stephen R., Jones, Jace W., Do, Christopher T., Braham, Pamela H., Bainbridge, Brian W., To, Thao T., Goodlett, David R., Ernst, Robert K., Darveau, Richard P.
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074576/
https://ncbi.nlm.nih.gov/pubmed/19552698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1462-5822.2009.01349.x
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