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Elucidation of IP6 and Heparin Interaction Sites and Conformational Changes in Arrestin-1 by Solution NMR

Arrestins specifically bind activated and phosphorylated G protein-coupled receptors, and orchestrate both receptor trafficking, and channel signaling to G protein-independent pathways via direct interactions with numerous non-receptor partners. Here we report the first successful use of solution NM...

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Autors principals: Zhuang, Tiandi, Vishnivetskiy, Sergey A., Gurevich, Vsevolod V., Sanders, Charles R.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074303/
https://ncbi.nlm.nih.gov/pubmed/21050017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101596g
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