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BR-squared: a practical solution to the winner’s curse in genome-wide scans

The detrimental effects of the winner’s curse, including overestimation of the genetic effects of associated variants and underestimation of sufficient sample sizes for replication studies are well-recognized in genome-wide association studies (GWAS). These effects can be expected to worsen as the f...

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Autors principals: Sun, Lei, Dimitromanolakis, Apostolos, Faye, Laura L., Paterson, Andrew D., Waggott, Daryl, Bull, Shelley B.
Format: Artigo
Idioma:Inglês
Publicat: Springer-Verlag 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3074069/
https://ncbi.nlm.nih.gov/pubmed/21246217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-011-0948-2
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