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Tirandamycins from Streptomyces sp. 17944 Inhibiting the Parasite Brugia malayi Asparagine tRNA Synthetase
[Image: see text] Lymphatic filariasis is caused by the parasitic nematodes Brugia malayi and Wuchereria bancrofti and asparaginyl-tRNA synthetase (AsnRS) is considered an excellent antifilarial target. The discovery of three new tirandamycins (TAMs), TAM E (1), F (2), and G (3), along with TAM A (4...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3074013/ https://ncbi.nlm.nih.gov/pubmed/21405052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol200420u |
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