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A live attenuated strain of Yersinia pestis KIM as a vaccine against plague
Yersinia pestis, the causative agent of plague, is a potential weapon of bioterrorism. Y. pestis evades the innate immune system by synthesizing tetra-acylated lipid A with poor Toll-like receptor 4 (TLR4)-stimulating activity at 37°C, whereas hexa-acylated lipid A, a potent TLR4 agonist, is made at...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3073832/ https://ncbi.nlm.nih.gov/pubmed/21320544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2011.01.099 |
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