A live attenuated strain of Yersinia pestis KIM as a vaccine against plague

Yersinia pestis, the causative agent of plague, is a potential weapon of bioterrorism. Y. pestis evades the innate immune system by synthesizing tetra-acylated lipid A with poor Toll-like receptor 4 (TLR4)-stimulating activity at 37°C, whereas hexa-acylated lipid A, a potent TLR4 agonist, is made at...

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Main Authors: Sun, Wei, Six, David, Kuang, Xiaoying, Roland, Kenneth L, Raetz, Christian R.H., Curtiss, Roy
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073832/
https://ncbi.nlm.nih.gov/pubmed/21320544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2011.01.099
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