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Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 β-cells and rat islets

Glucose-stimulated insulin secretion [GSIS] involves interplay between small G-proteins and their regulatory factors. Herein, we tested the hypothesis that Arf nucleotide binding site opener [ARNO], a guanine nucleotide exchange factor [GEF] for the small G-protein Arf6, mediates the functional acti...

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Bibliografiske detaljer
Main Authors: Jayaram, Bhavaani, Syed, Ismail, Kyathanahalli, Chandrashekara N., Rhodes, Christopher J., Kowluru, Anjaneyulu
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073812/
https://ncbi.nlm.nih.gov/pubmed/21276423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2011.01.006
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