Sindbis virus replication, is insensitive to rapamycin and torin1, and suppresses Akt/mTOR pathway late during infection in HEK cells

Genetically engineered Sindbis viruses (SIN) are excellent oncolytic agents in preclinical models. Several human cancers have aberrant Akt signaling, and kinase inhibitors including rapamycin are currently tested in combination therapies with oncolytic viruses. Therefore, it was of interest to delin...

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Bibliographic Details
Main Authors:	Mohankumar, Vidyarani, Dhanushkodi, Nisha R., Raju, Ramaswamy
Format:	Artigo
Language:	Inglês
Published:	2011
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3073402/ https://ncbi.nlm.nih.gov/pubmed/21316343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.02.030
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Sindbis virus replication, is insensitive to rapamycin and torin1, and suppresses Akt/mTOR pathway late during infection in HEK cells

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