Cyclin D1b protein expression in breast cancer is independent of cyclin D1a and associated with poor disease outcome

Aberrant expression of cyclin D1 protein is a common feature of breast cancer. However, the CCND1 gene encodes two gene products, cyclin D1a and cyclin D1b, which have discrete mechanisms of regulation and impact on cell behavior. A polymorphism at nucleotide 870 in the CCND1 gene, rs603965, influen...

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Autori principali: Millar, EKA, Dean, JL, McNeil, CM, O’Toole, SA, Henshall, SM, Tran, T, Lin, J, Quong, A, Comstock, CES, Witkiewicz, A, Musgrove, EA, Rui, H, LeMarchand, L, Setiawan, VW, Haiman, CA, Knudsen, KE, Sutherland, RL, Knudsen, ES
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073345/
https://ncbi.nlm.nih.gov/pubmed/19287456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.13
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