Differential Role of DNA-PKcs Phosphorylations and Kinase Activity in Radiosensitivity and Chromosomal Instability

The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is the key functional element in the DNA-PK complex that drives nonhomologous end joining (NHEJ), the predominant DNA double-strand break (DSB) repair mechanism operating to rejoin such breaks in mammalian cells after exposure to ioniz...

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Bibliografiset tiedot
Päätekijät: Nagasawa, Hatsumi, Little, John B., Lin, Yu-Fen, So, Sairei, Kurimasa, Akihiro, Peng, Yuanlin, Brogan, John R., Chen, David J., Bedford, Joel S., Chen, Benjamin P. C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073160/
https://ncbi.nlm.nih.gov/pubmed/21175350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR2092.1
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