RXRα ablation in epidermal keratinocytes enhances UV radiation induced DNA damage, apoptosis, and proliferation of keratinocytes and melanocytes

We show here that keratinocytic nuclear receptor Retinoid X Receptor α (RXRα) regulates mouse keratinocyte and melanocyte homeostasis following acute ultraviolet radiation (UVR). Keratinocytic RXRα has a protective role on UVR-induced keratinocyte and melanocyte proliferation/differentiation, oxidat...

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Autors principals: Wang, Zhixing, Coleman, Daniel J., Bajaj, Gaurav, Liang, Xiaobo, Ganguli-Indra, Gitali, Indra, Arup Kumar
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3073005/
https://ncbi.nlm.nih.gov/pubmed/20944655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2010.290
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