Genetic Analysis of the Neurosteroid Deoxycorticosterone and Its Relation to Alcohol Phenotypes: Identification of QTLs and Downstream Gene Regulation

BACKGROUND: Deoxycorticosterone (DOC) is an endogenous neurosteroid found in brain and serum, precursor of the GABAergic neuroactive steroid (3α,5α)-3,21-dihydroxypregnan-20-one (tetrahydrodeoxycorticosterone, THDOC) and the glucocorticoid corticosterone. These steroids are elevated following stress...

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Detalhes bibliográficos
Main Authors: Porcu, Patrizia, O'Buckley, Todd K., Song, Soomin C., Harenza, Jo Lynne, Lu, Lu, Wang, Xusheng, Williams, Robert W., Miles, Michael F., Morrow, A. Leslie
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072994/
https://ncbi.nlm.nih.gov/pubmed/21494628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018405
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